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產(chǎn)品中心您現(xiàn)在的位置：首頁 > 產(chǎn)品展示 > > 蛋白&肽 > α2-Macroglobulin (human plasma), (purified)

α2-Macroglobulin (human plasma), (purified)

更新時間：2022-01-28

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α2-Macroglobulin (human plasma), (purified)
品牌： ENZO產(chǎn)品貨號： BML-SE502-0001規(guī)格： 1*1mg
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型號：廠商性質(zhì)：代理商瀏覽量：1041

α2-Macroglobulin (human plasma), (purified)

Product Details

MW:	725 kDa

Source:	Isolated from human plasma that is tested to be negative for HbsAg, anti-HBc, anti-HCV, and anti-HIV-1 and -2.

UniProt ID:	P01023

Shipping:	Shipped on Blue Ice

Long Term Storage:	-20°C

Scientific Background:	In addition to binding TGF-β and β-amyloid, α2-macroglobulin covalently binds and inhibits a wide range of proteases, including ADAMs, calpains, cathepsins, chymase, clotting factors, kallikreins, MMPs, neutrophil elastase, and proteinase 3. It also plays a role in the innate immune system, inhibiting parasitic proteases. When treated with methylamine, it blocks binding of apoE to lipoprotein receptor-related protein (LRP).

Regulatory Status:	RUO - Research Use Only

Product Literature References

Cytotoxicity mechanism of α-MMC in normal liver cells through LRP1 mediated endocytosis and JNK activation: L. Wang, et al.; Toxicology 357, 33 (2016), Abstract;

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α2-Macroglobulin (human plasma), (purified)

Product Details

Product Literature References

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