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Enzo Life Sciences熱銷品介紹:15-脫氧-Δ12,14-前列腺素J2 ELISA試劑盒

更新時間:2024-09-20   點擊次數(shù):775次

首-款上市的15-d-PGJ2 ELISA試劑盒,可用于類花生酸研究

 

15-deoxy-Δ12,14-PGJ2(15-d-PGJ2)是PGD2的最終脫水產(chǎn)物之一,通過中間體Δ12-PGJ2形成。生理條件下,15-d-PGJ2存在于體液中,濃度介于10^(-12)至10^(-9)M,但在感染和炎癥等應(yīng)激條件下會急劇增加。在細胞類型和濃度的影響下,15-d-PGJ發(fā)揮促進和抗炎癥作用,其中許多作用是通過與過氧化物酶體增殖劑激活受體(PPAR-γ)的γ異構(gòu)體結(jié)合而介導(dǎo)的。15-d-PGJ2似乎通過一種與PPAR-γ無關(guān)的機制誘導(dǎo)HO-1的表達,該機制由活性氧(ROS)的產(chǎn)生介導(dǎo)。


Enzo Life Sciences的15-脫氧-Δ12,14-前列腺素J2 ELISA試劑盒是一種比色競爭法酶聯(lián)免疫檢測試劑盒,可在5小時內(nèi)得到檢測結(jié)果,相比GC/MS 分析節(jié)省時間且耗時少得多。欣博盛生物作為Enzo Life Sciences授權(quán)中國一級代理,可提供該產(chǎn)品,歡迎咨詢。

 

產(chǎn)品特色

◆ 靈敏度高,可測量低至36.8 pg/ml的15-deoxy-Δ12,14-PGJ2

◆ 檢測快速,較GC/MS分析耗時少得多

◆ 易于使用的即用型液體顏色編碼試劑,可減少錯誤

◆ 優(yōu)于半定量Western blot分析的完-全定量檢測

  

產(chǎn)品信息

產(chǎn)品貨號

ADI-900-023/ ADI-901-023

產(chǎn)品名稱

15-deoxy-Δ12,14-PGJ2 ELISA kit(15-脫氧-Δ12,14-前列腺素J2 ELISA試劑盒)

規(guī)格

96 wells/ 5x96 wells

其他名稱

15-deoxy-Δ12,14-Prostaglandin J2

靈敏度

36.8 pg/ml

檢測范圍

195 - 200,000 pg/ml

檢測時間

5 hours

應(yīng)用

ELISA, Colorimetric detection

檢測波長

405 nm

樣本類型

細胞培養(yǎng)上清,血漿,唾液和尿液

適用種屬

不限種屬

試劑盒組分

GxR IgG Microtiter plate, Conjugate, Antibody, Assay buffer, Wash buffer concentrate, 

Standard, pNpp Substrate, Stop solution

 

標曲示例

15-deoxy-Δ12,14-PGJ2 ELISA kit——ENZO熱銷產(chǎn)品 

 

部分產(chǎn)品引用文獻

1. Redox aspects of cytotoxicity and anti-neuroinflammatory profile of chloroquine and hydroxychloroquine in serum-starved BV-2 microglia: L. Ra?ková, et al.; Toxicol. Appl. Pharmacol. 447, 116084 (2022)

2. Fluoxetine‐induced hepatic lipid accumulation is mediated by prostaglandin endoperoxide synthase 1 and is linked to elevated 15‐deoxy‐Δ12, 14PGJ2: A. Ayyash, et al.; J. Appl. Toxicol. 4272, 1002 (2021)

3. Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis: C.D. Wiley, et al.; Cell Metab. 33, 1124 (2021)

4. Cocaine-mediated circadian reprogramming in the striatum through dopamine D2R and PPARγ activation: K. Brami-Cherrier, et al.; Nat. Commun. 11, 4448 (2020)

5. Thymopentin improves the survival of septic mice by promoting the production of 15-deoxy-prostaglandin J2 and activating the PPARγ signaling pathway: Y. Zhang, et al.; FASEB J. 34, 11772 (2020)

6. Apolipoprotein D overexpression alters hepatic prostaglandin and omega fatty acid metabolism during the development of a non-inflammatory hepatic steatosis: F. Desmarais, et al.; Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1864, 522 (2019)

7. Association of chronic inflammation and perceived stress with abnormal functional connectivity in brain areas involved with interoception in hepatitis C patients: G. Oriolo, et al.; Brain Behav. Immun. 80, 204 (2019)

8. Programming of macrophages by UV-irradiated apoptotic cancer cells inhibits cancer progression and lung metastasis: Y.B. Kim, et al.; Cell. Mol. Immunol. 16, 851 (2019)

9. Arachidonic acid induces ARE/Nrf2-dependent heme oxygenase-1 transcription in rat brain astrocytes: C.C. Lin, et al.; Mol. Neurobiol. 55, 3328 (2018)

10. Bone-marrow-derived mesenchymal stem cells inhibit gastric aspiration lung injury and inflammation in rats: J. Zhou, et al.; J. Cell Mol. Med. 20, 1706 (2016)

11. Implications of a genetically determined nitric oxide deficit for endothelial cell-leukocyte interaction and cardiovascular disease: I. Kadiyska; (2016)

12. CRTH2 is a critical regulator of neutrophil migration and resistance to polymicrobial sepsis: M. Ishii, et al.; J. Immunol. 188, 5655 (2012)

13. Choroidal involution is a key component of oxygen-induced retinopathy: Z. Shao, et al.; Invest. Ophthalmol. Vis. Sci. 52, 6238 (2011)

14. Response of chondrocytes to shear stress: antagonistic effects of the binding partners Toll-like receptor 4 and caveolin-1: P. Wang, et al.; FASEB J. 25, 3401 (2011)

15. The myocardial infarct size-limiting effect of sitagliptin is PKA-dependent, whereas the protective effect of pioglitazone is partially dependent on PKA: Y. Ye, et al.; Am. J. Physiol. Heart Circ. Physiol. 298, H1454 (2010)

 

 

15-deoxy-Δ12,14-PGJ2 ELISA kit——ENZO熱銷產(chǎn)品

詳情請聯(lián)系 ENZO 金牌代理商-欣博盛生物科技

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